Diacerein, Glucosamine Sulphate, Potassium Chloride, and Methyl Sulfonyl Methane. Diacerein is a proteoglycan synthesis stimulator. They are used together in the building of cartilage (joint repair) and inflammation (swelling). The effect of Methyl Sulfonyl Methane (MSM) is two fold: First, it helps lower inflammation by reducing the total joint weight. Secondly, it comes from gut microbiome research – many strains of bacteria produce MSM and much research is being conducted to see how this can be used for humans too.